|
KMID : 1024520030120010077
|
|
Journal of the Environmental Sciences
2003 Volume.12 No. 1 p.77 ~ p.80
|
|
|
Analysis of the Interactive Characteristic of Environmental Toxic Peptide and Phospholipid
|
|
Lee Bong-Hun
Park Heung-Jai
|
|
|
Abstract
|
|
|
|
The interaction of mastoparan B, a cationic tetradecapeptide amide isolated from the hornet Vespa basalis, with phospholipid bilayers was studied with synthetic mastoparan B and its analogue with Ala instead of hydrophobic 12th amino acid residue in mastoparan B. MP-B and its derivative, [12-Ala]MP-B were synthesized by the solid-phase peptide synthesis method. MP-B and its analogue, [12-Ala]MP-B adopted an unordered structure in buffer solution. In the presence of neutral and acidic liposomes, the peptides took an -helical structure. The two peptides interacted with neutral and acidic lipid bilayers. These results indicated that the hydrophobic face in the amphipathic -helix of MP-B critically affected the biological activity and helical content.
|
|
|
KEYWORD
|
|
|
Interaction, Toxic peptide, Liposome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|